When we become dehydrated, histamine sees to it that the available water in the body is well preserved and distributed according to a priority of function. The rate of histamine production in the body increases exponentially when the body becomes more and more dehydrated.

Supplying the body with water causes a disappearance of histamine from areas where it should not be present. With adequate water supply, histamine production, and its excess release, is inhibited proportionately. This relationship of water to histamine has been demonstrated in several animal experiments. It is now physiologically apparent that water by itself has very strong natural antihistamine properties.